You woke up late, left the house, and attended a meeting as soon as you entered the office. You’ve never had breakfast, and by the time you sit down to lunch, it’s been about 15 hours since your last meal. You should be starving, but instead you feel nauseous. One of the most common causes of this phenomenon is easy to understand for Christine Lee, gastroenterologist at the Cleveland Clinic.
Your stomach is breaking down food, energy and produces hydrochloric acid as part of a long process to do what it can for the materials and dispose of the rest.
If you don’t eat for a long time, hydrochloric acid can build up in the stomach.
Another possible reason for feeling nauseous when hungry It also has to do with your body’s signal network to know when to eat. These signals are regulated by an endocrine system that uses the bloodstream for chemical communication (pituitary glandthyroid gland and pancreas).
The hormones produced by the endocrine system ‘give your body the information it needs to balance its chemical levels.
Your stomach is sending signals to the endocrine system
For example, you need calories to maintain healthy blood sugar levels and support a wide variety of bodily activities. Your stomach sends signals to the endocrine system that trigger the release of hormones.
These hormones tell the brain, “Give us more calories” or “Enough is enough.” There are many hormones, but two key players are ghrelin and leptin.
“Ghrelin is supposed to cause hunger,” Lee said.
The hormone was discovered in 1999, but since then, researchers have found ghrelin in the body. bowel They identified it as a key player in many important processes, including motility, gastric acid secretion, sense of taste, and glucose metabolism.
Leptin has the opposite effect: It reduces appetite. There are many other hormones involved in feelings of hunger, but the interaction between ghrelin and leptin is key to appetite flow.
When you eat, your body releases leptin, which indicates that you don’t need to fast for a while. In other words, your body needs food, so it produces ghrelin. This makes you hungry. At that time, your body does not need any more food, so it produces leptin. This makes you feel full so you stop eating.
However, if you ignore the hunger signals and don’t eat regularly, chemical balancing may be disturbed.
“Some people are more sensitive to hormonal levels,” Lee said.
The change in sensitivity and other factors cause some people to experience mild nausea when they are extremely hungry. However, more serious nausea symptomsmay indicate illness.
ghrelin: Ghrelin is a 28 amino acid hunger stimulating peptide and hormone formed mainly by P/D1 cells in the fundus of the stomach and epsilon cells in the pancreas. Ghrelin levels rise before meals and then fall.
leptin: Leptin, also called “satiety hormone”, is a hormone from the class of peptides that regulates fat stocks and appetite in the organism by creating a feeling of satiety. leptin; It is secreted from adipose tissue, which is the body’s largest endocrine organ.
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